Corelatii dintre structura chimica a sulfamidelor si proprietatile antibacteriene

      CUPRINS
Cap.        1.        Sulfonamide,        prezent         şi         viitor
.................................................... 1
     1.                      Istoricul                       sulfonamidelor
        .......................................................... 1
     2.         Clasificarea         sulfonamidelor          antimicrobiene
        ........................... 4
      1.3Corelaţii între structura chimică şi activitatea microbiană  ......
      5
      1.4Metode              generale               de               sinteză
      ..................................................... 6
Cap.      2.      Activitatea      antimicrobiană      a      sulfonamidelor
........................... 13
                 2.1            Spectru            de             activitate
............................................................. 13
          2.2     Mecanismul     de      acţiune      al      sulfonamidelor
............................ 15
      2.3                       Utilizări                        terapeutice
.............................................................. 19
Cap.           3.           Sulfonamide            N1            substituite
....................................................... 20
      3.1   Sulfamide   tiazolice   (cu   acţiune    de    scurtă    durată)
................. 20
                                   3.1.1                         Sulfatiazol
................................................................ 21
                     3.2                Sulfamide                izoxazolice
........................................................... 24
                                  3.2.1.                        Sulfafurazol
............................................................. 24
                                  3.2.2                       Sulfametoxazol
......................................................... 27
                    3.3                Sulfamide                pirimidinice
.......................................................... 28
                                   3.3.1                        Sulfadiazina
.............................................................. 28
      3.4                       Sulfonamide                       pirazinice
.......................................................... 32
                                    3.4.1                         Sulfalenul
................................................................. 32
Cap.4.       Sulfonamide       N1       substituite,       N4        acilate
....................................... 33
      4.1                      Caracteristici                       generale
........................................................... 33
     2.                                                 Ftalilsulfatiazolul
        ...................................................................
        34
PARTEA a II-a
CONTRIBUŢII PERSONALE
                       Obiectivele lucrarii
1 CAPITOL 5
TESTAREA FARMACOTOXICITĂŢII COTRIMOXAZOLULUI
                    1. MODEL EXPERIMENTAL
                       5.1.1 Calculul dozei de cotrimoxazol
                    2. MATERIAL ŞI METODE
                        5.2.1 Determinarea cantitativă a
                       aminotransferazelor
   3.  REZULTATE ŞI DISCUŢII
CONCLUZII
Bibliografie................................................................
...............................49